This page provides a list of placeholders for project settings that can be used in report templates for PKanalix projects.
| Keyword | Description | Possible values |
| %NCA_administrationType% | Administration type for NCA parameter calculation. | “intravenous” or “extravascular” if one adm id, otherwise “1: intravenous, 2: extravascular” with 1/2 corresponding to the administration id |
| %NCA_ObsIdUsed% | Observation id used for the NCA calculations. | string of the observation id, e.g “PK” or “1” |
| %data_type% | Type of data defined on the Data page. | “plasma” or “urine” if one observation id, otherwise “PK: plasma, PD: plasma” with PK/PD corresponding to the observation ids |
| %NCA_integralMethod% | Method for AUC and AUMC calculation and interpolation. | as in the associated dropdown menu (linear trapezoidal linear, linear log trapezoidal, linear up log down, linear trapezoidal linear/log) |
| %NCA_blqMethodBeforeTmax% | Method by which the BLQ data before Tmax should be replaced. | as in the associated dropdown menu (missing, zero, LOQ, LOQ/2) |
| %NCA_blqMethodAfterTmax% | Method by which the BLQ data after Tmax should be replaced. | as in the associated dropdown menu (missing, zero, LOQ, LOQ/2) |
| %NCA_ajdr2AcceptanceCriteria% | Value of the adjusted R2 acceptance criteria for the estimation of lambda_Z. | a number |
| %NCA_extrapAucAcceptanceCriteria% | Value of the AUC extrapolation acceptance criteria for the estimation of lambda_Z. | a number |
| %NCA_spanAcceptanceCriteria% | Span acceptance criteria for the estimation of lambda_Z. | a number |
| %NCA_lambdaRule% | General rule for the lambda_Z estimation. Includes information about the main rule, together with settings defined in the “rules” tab. | Examples: “R2 with maximum 500 points, minimum time 20” “Time interval between 10 and 50” “Fixed number of points (3 points)” |
| %NCA_lambdaWeighting% | Weighting used for the lambda_Z estimation. | as in the associated dropdown menu (uniform, 1/Y, 1/Y²) |
| %CA_cost% | Cost function used for CA. | as in the associated dropdown menu ((Ypred – Yobs)², (Ypred – Yobs)² / Yobs, (Ypred – Yobs)² / Ypred, (Ypred – Yobs)² / Yobs², (Ypred – Yobs)² / Ypred², (Ypred – Yobs)² / |Ypred * Yobs|) |
| %CA_method% | Fit with individual parameters or with the same parameters for all individuals. | pooled fit, individual fit |
| %CA_blqMethod% | BLQ method for CA. | as in the associated dropdown menu (missing, zero, LOQ, LOQ/2) |
| %BE_level% | Level of the confidence interval for bioequivalence | a number |
| %BE_limits% | Limits in which the confidence interval must be to conclude the bioequivalence is true | Two numbers separated by a comma. Example: 0.8, 1.25 |
| %BE_linearModelFactors% | Factors tested in the linear model for bioequivalence. | Data set column names. Example: ID, PERIOD, FORM, SEQ |
| %BE_design% | Design of a bioequivalence study. | parallel, crossover |
| %BE_reference% | Categorical covariate modality selected as a reference | One of the modalities present in the data set. Example: REF or IV |
| %TotalNbSubjects% | Total number of subjects in the data set (all observation ids together). | a number |
| %TotalNbSubjectsOcc% | Total number of subjects-occasions in the dataset (all observation ids together). | a number |
| %AvgNbDosesPerSubject% | Average number of doses per subject (any administration id, any occasion, all observation ids). | a number |
| %TotalNbObservations% | Total number of observations in the data set. | if one obs id, number, if several obs id, PK: xx, PD: xx |
| %AvgNbObservationsPerID% | Average number of observations per id (all occasions together). | if one obs id, number, if several obs id, PK: xx, PD: xx |
| %MinNbObservationsPerID% | Minimum number of observations per id (all occasions together). | if one obs id, number, if several obs id, PK: xx, PD: xx |
| %MaxNbObservationsPerID% | Maximum number of observations per id (all occasions together). | if one obs id, number, if several obs id, PK: xx, PD: xx |
| %PercentCensoredObservations% | Percentage of censored observations. | if one obs id, number, if several obs id, PK: xx, PD: xx |
| %StructModelCode% | Mlxtran code for the structural model. | whole structural model file content, as shown in the CA model tab |
| %reportGenerationDateTime(yyyy-MM-dd HH:mm:ss)% | Report generation date and time. Part of yyyy-MM-dd HH:mm:ss can be removed or reordered. | yyyy-MM-dd HH:mm:ss |
| %system% | Operating system on which report was generated. | Linux, macOS, Windows |
| %version% | Version of PKanalix with which report was generated. | 2023R1 |
| %project_fileName% | File name of the project (without path). | Example: NCA_run.pkx |
| %project_filePath% | File path of the project. | Example: C:/Users/user/lixoft/monolix/monolix2024R1/demos/1.creating_and_using_models/1.1.libraries_of_models/theophylline_project.mlxtran |
| %data_fileName% | File name of the data set (without path). | Example: data.csv |
